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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Graded ephrin-A2 expression in the developing hamster superior colliculus.

During development, ephrin gradients guide retinal ganglion cell axons to their appropriate topographic locations in the superior colliculus (SC). Expression of ephrin-A2, assessed immunohistochemically in the developing hamster SC, revealed a rostral(low )to caudal(high) gradient that is most prominent at postnatal days (P)4 and P7 when topography is established. Double-labelling immunohistochemistry for ephrin-A2 and cell specific markers revealed that ephrin-A2 is expressed exclusively by a subset of neurons. The expression pattern has implications for mechanisms underlying establishment of topography during development and following injury.[1]

References

  1. Graded ephrin-A2 expression in the developing hamster superior colliculus. Lukehurst, S.S., King, C.E., Beazley, L.D., Tay, D.K., So, K.F., Rodger, J. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2006) [Pubmed]
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