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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Neuregulin-1 isoform induces mitogenesis, K(Ca) and Ca(2+) currents in PC12 cells. A comparison with sciatic nerve conditioned medium.

Neuregulin-1 ( NRG-1) is an active component found in sciatic nerve conditioned medium (CM). NRG-1 is a growth and differentiation factor shown to have an effect on neuritogenesis and survival of neural cells. PC12 cells chronically treated with NRG-1 (beta1 isoform) show an increase in proliferation under low-serum condition (2.5% fetal bovine serum and 1.25% horse serum) and serum deprivation, without visible morphological changes. NRG-1 and CM treatments of PC12 cells induced an increase of voltage-activated Ca(2+) currents and large-conductance calcium-activated K(+) currents (K(Ca)). AG825, a specific inhibitor for erbB2 receptor, abolishes K(Ca) current, though Ca(2+) currents were not inhibited. These results showed that NRG-1 is capable of inducing functional changes but is not sufficient on its own to have an effect on cell morphology.[1]

References

  1. Neuregulin-1 isoform induces mitogenesis, K(Ca) and Ca(2+) currents in PC12 cells. A comparison with sciatic nerve conditioned medium. Castillo, C., Malavé, C., Martínez, J.C., Núñez, J., Hernández, D., Pasquali, F., Villegas, G.M., Villegas, R. Brain Res. (2006) [Pubmed]
 
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