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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Stability indicating assay for fetindomide (NSC 373965), a potential prodrug of mitindomide (NSC 284356), employing high-performance liquid chromatography.

A stability indicating assay for fetindomide using reversed-phase high-performance liquid chromatography (HPLC) has been developed. The chromatography was performed on a MOS Hypersil (C(8)) column and was optimized by investigating the effects of methanol (7.5-20%), acetonitrile (5-7%), tetrabutylammonium hydrogen-sulphate (TBA, 0-90 mM) and acetate buffer (pH 3.5, 60-100 mM) on the retention of fetindomide and mitindomide. The optimum mobile phase was 5% acetonitrile in an aqueous solution containing 100 mM acetate buffer (pH 3.5) and 40 mM TBA. Complete resolution of fetindomide, and its degradation products, phenylalanine, the two isomers of N-phenylalanyloxymethylmitindomide and mitindomide was achieved within 10 min at a flow rate of 2 ml/min. The method is linear, accurate and precise for the determination of fetindomide and mitindomide and was applied to study the stability of fetindomide in various aqueous media.[1]

References

  1. Stability indicating assay for fetindomide (NSC 373965), a potential prodrug of mitindomide (NSC 284356), employing high-performance liquid chromatography. Umprayn, K., Stella, V.J., Riley, C.M. Journal of pharmaceutical and biomedical analysis. (1987) [Pubmed]
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