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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Affinity of a 1,4-benzodioxane derivative with alpha-adrenolytic activity to isolated synaptic membranes from rat brain.

The experiments carried out with KS 5-2, dibozan and WB 4101 allowed for a comparison of the affinity of KS 5-2 with that of the other two compounds. High affinity of the three compounds and differences in their affinity with respect to the alpha-adrenergic receptors were established. The results were compared with the 1H-NMR spectroscopic data, revealing the intimate structure of WB 4101, dibozan and KS 5-2 in such a way as to substantiate their pharmacological action by their chemical structure.[1]

References

  1. Affinity of a 1,4-benzodioxane derivative with alpha-adrenolytic activity to isolated synaptic membranes from rat brain. Spassov, V., Danchev, N. Acta physiologica et pharmacologica Bulgarica. (1991) [Pubmed]
 
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