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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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VIP and PACAP receptor pharmacology: a comparison of intracellular signaling pathways.

VIP/PACAP receptor activation stimulates the production of [cAMP]i and [Ca2+]i by coupling to independent G-protein subunits, although agonist potencies for the different transduction pathways appear to differ. Using CHO-K1 cells stably expressing the human VIP/ PACAP receptors (hVPAC1R, hVPAC2R, and hPAC1R), functional assays ([cAMP]i and [Ca2+]i) were established and the receptor pharmacology was characterized with five peptide agonists (VIP, PACAP-27, PACAP-38, [Ala(11,22,28)]VIP, and R3P65). The rank order of potency (ROP) was consistent between assays for the individual receptor subtypes, however, higher agonist concentrations (approximately 100-fold) were required for stimulating [Ca2+]i when compared to [cAMP]i.[1]

References

  1. VIP and PACAP receptor pharmacology: a comparison of intracellular signaling pathways. Dickson, L., Aramori, I., Sharkey, J., Finlayson, K. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
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