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Seki, T. et al.

Seki, Hinohara, Taki, Nakatani, Ozawa, Nishimura, Takaki, Itho, Takenoya, Shioda,

PACAP stimulates the release of interleukin-6 in cultured rat MÃ¼ller cells.

We have investigated the in vivo effect of PACAP on rat MÃ¼ller cells that are the predominant glial element in the retina. MÃ¼ller cells were treated with PACAP38, either alone or in the presence of the PACAP-selective antagonist, PACAP6-38. Cellular proliferation was determined by measuring the incorporation of bromodeoxyuridine, while interleukin-6 (IL-6) levels in the culture medium were examined using a B9 cell bioassay. In cultured rat MÃ¼ller cells, the expression of PACAP receptor (PAC1-R) was assessed with immunohistochemistry using a PAC1-R-specific antiserum. PACAP stimulated IL-6 production in MÃ¼ller cells at a concentration as low as 10(-12) M, which was not sufficient to induce cell proliferation. This elevation of IL-6 production was significantly inhibited by PACAP6-38. These data suggest that MÃ¼ller cells are one of the target cells for PACAP, stimulating the release of IL-6, and providing a mechanism whereby PACAP exerts a significant neuroprotective effect in the retina.[1]

References

PACAP stimulates the release of interleukin-6 in cultured rat Müller cells. Seki, T., Hinohara, Y., Taki, C., Nakatani, M., Ozawa, M., Nishimura, S., Takaki, A., Itho, H., Takenoya, F., Shioda, S. Ann. N. Y. Acad. Sci. (2006) [Pubmed]

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