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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Intra- and intersubtype alternative Pak2- activating structural motifs of human immunodeficiency virus type 1 Nef.

The design of antiviral strategies against human immunodeficiency virus type 1 (HIV-1) has been largely derived from studies of subtype B viruses, although they constitute only 12% of infections worldwide. At 50% of all HIV-1 infections worldwide, subtype C viruses are the most predominant. Here, we present evidence that subtype C Nefs display functional Pak2-activating motifs that differ from those found in subtype B and E Nefs. The identification of multiple Pak2- activating structural motifs that singly affect one Nef activity revealed a functional plasticity that has implications for future drug and vaccine design aimed at HIV-1 Nef and its effects on the deregulation of the immune system.[1]

References

  1. Intra- and intersubtype alternative Pak2-activating structural motifs of human immunodeficiency virus type 1 Nef. O'Neill, E., Baugh, L.L., Novitsky, V.A., Essex, M.E., Garcia, J.V. J. Virol. (2006) [Pubmed]
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