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Varaprasad, C.V. et al.

Varaprasad, Ramasamy, Girardet, Gunic, Lai, Zhong, An, Hong,

Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents.

Several Toyocamycin (4) analogues were examined for their ability to inhibit HCV RNA in a replicon assay. Among the compounds examined 4-methylthio (18) and 5-carboxamide oxime derivatives (23 and 27) of Toyocamycin were found to have good activity and selectivity.[1]

References

Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents. Varaprasad, C.V., Ramasamy, K.S., Girardet, J.L., Gunic, E., Lai, V., Zhong, W., An, H., Hong, Z. Bioorg. Chem. (2007) [Pubmed]

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