Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Inoue, K. et al.

Development of Stable Isotope Dilution Quantification Liquid Chromatography-Mass Spectrometry Method for Estimation of Exposure Levels of Bisphenol A, 4-tert-Octylphenol, 4-Nonylphenol, Tetrabromobisphenol A, and Pentachlorophenol in Indoor Air.

The potential risks to human health and reproduction of phenolic xenoestrogens, such as bisphenol A (BPA), 4-tert-octylphenol (OP), 4-nonylphenol (NP), tetrabromobisphenol A (TBBPA), and pentachlorophenol (PCP), have not been fully elucidated. It is possible that healthy humans are exposed to phenolic xenoestrogens in their daily lives. It is also possible that the source of human exposure to trace amounts of phenolic xenoestrogens is indoor air. Therefore, we have established an accurate, sensitive, and selective method for determining BPA, OP, NP, TBBPA, and PCP in air samples by using stable isotope dilution techniques using (13)C(12)-BPA, 4-(1-methyl) octylphenol-d(5) (m-OP-d(5)), (13)C(12)-TBBPA, (13)C(6)-PCP, and liquid chromatography-mass spectrometry (LC-MS). Air sampling (71/min, 24 hours), using glass filters (GB-100R, 47 mm) and Empore SDB-XD filters (47 mm/0.5 mm, 3M, Tokyo, Japan) and subsequent extraction by washing were carried out. Then the extracted sample solution was subjected to LC-MS. The percentage recovery of these analytes ranged from 87.0% to 101.9% (SD 0.2% to 4.6%, n = 3) with correction using the stable isotope dilution quantification method. The quantification limit (signal-to-noise ratio, S/N>10) in the air samples was 0.1 ng/m(3). Our findings suggest that the LC-MS method can detect low levels of phenolic xenoestrogens in air samples and that these trace levels of analytes exist in indoor air.[1]

References

Development of Stable Isotope Dilution Quantification Liquid Chromatography-Mass Spectrometry Method for Estimation of Exposure Levels of Bisphenol A, 4-tert-Octylphenol, 4-Nonylphenol, Tetrabromobisphenol A, and Pentachlorophenol in Indoor Air. Inoue, K., Yoshida, S., Nakayama, S., Ito, R., Okanouchi, N., Nakazawa, H. Arch. Environ. Contam. Toxicol. (2006) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.