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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CSF somatostatin in childhood psychiatric disorders: a preliminary investigation.

Disruptive behavior disorders and obsessive-compulsive disorder have been associated with serotonergic dysfunction as well as particular body habitus findings in pediatric patients. Somatostatin, a peptide which stimulates serotonin release and inhibits growth hormone release, was measured in the cerebrospinal fluid (CSF) of 10 children with disruptive behavior disorders and in 10 age-, sex-, and race-matched pairs of obsessive-compulsive disorder patients. Decreased concentrations of somatostatin were found in disruptive behavior disorder patients relative to obsessive-compulsive children, even after controlling for differences in Tanner stage. In contrast to studies in adults, those patients in a depressed state did not have lower CSF somatostatin concentration.[1]

References

  1. CSF somatostatin in childhood psychiatric disorders: a preliminary investigation. Kruesi, M.J., Swedo, S., Leonard, H., Rubinow, D.R., Rapoport, J.L. Psychiatry research. (1990) [Pubmed]
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