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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Studies on the primary sequence requirements for PKC-alpha, -beta 1 and -gamma peptide substrates.

The substrate specificity of purified PKC-alpha, -beta and -gamma has been investigated. A series of synthetic peptides based upon the sequence surrounding serine-7 in glycogen synthase were generated and used to determine the basic residue requirements of these PKC isotypes. While PKC-alpha and -beta are indistinguishable in their phosphorylation of these peptides, PKC-gamma shows a distinct specificity profile for these synthetic substrates.[1]

References

  1. Studies on the primary sequence requirements for PKC-alpha, -beta 1 and -gamma peptide substrates. Marais, R.M., Nguyen, O., Woodgett, J.R., Parker, P.J. FEBS Lett. (1990) [Pubmed]
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