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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Salivary defense mechanisms in juvenile periodontitis.

The local, saliva-associated defense mechanisms of 28 juvenile periodontitis ( JP) patients and their age- and sex-matched controls were studied. Lysozyme, lactoferrin, salivary peroxidase, myeloperoxidase, and thiocyanate concentrations were determined from both whole saliva and parotid saliva. The total concentrations of salivary IgA, IgG, and IgM were assayed. The periodontal condition and the salivary flow rates were registered. Among the JP patients, a significantly elevated concentration of IgG was found in parotid saliva but not in whole saliva. Salivary peroxidase activities were significantly low both in the whole and in the parotid saliva samples of the JP patients, and leukocyte-derived myeloperoxidase was present in significantly low amounts in whole saliva of these patients. Because both glandular (salivary peroxidase) and polymorphonuclear-cell-derived (myeloperoxidase) enzyme activities were low among the JP patients, suppressed peroxidase-mediated host defense mechanisms could be characteristic of JP.[1]

References

  1. Salivary defense mechanisms in juvenile periodontitis. Saxén, L., Tenovuo, J., Vilja, P. Acta Odontol. Scand. (1990) [Pubmed]
 
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