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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Compounds with DNA cleaving activity from Kadsura ananosma.

Two DNA cleavage agents, meso-dihydroguaiaretic acid (1) and isobavachalcone (2) together with the known alpha-ylangene, beta-sitosterol, daucosterol, pentacosane, hexacosanic acid and cerotic acid 1-monoglyceride were isolated from the stem barks of Kadsura ananosma Kerr for the first time. Compounds 1 and 2 showed relaxation of supercoiled DNA to nicked DNA. 1 represented a new structural type of DNA cleavage agent, while 2 was reported to show DNA strand-scission activity for the first time. 1 also showed significant cytotoxic effect on Hela and Leukemia cells in vitro.[1]

References

  1. Compounds with DNA cleaving activity from Kadsura ananosma. Chen, Y.G., Song, X.P., Hai, L.N., Lv, Y.P., Fang, A., Halaweish, F., Liao, X.R. Die Pharmazie. (2006) [Pubmed]
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