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Nakamuta, M. et al.

Nakamuta, Kohjima, Morizono, Yoshimoto, Miyagi, Sakai, Enjoji, Kotoh,

Comparison of tissue pressure and ablation time between the LeVeen and cool-tip needle methods.

ABSTRACT: BACKGROUND: Radio frequency ablation (RFA) has been accepted clinically as a useful local treatment for hepatocellular carcinoma ( HCC). However, intrahepatic recurrence after RFA has been reported which might be attributable to increase in intra-tumor pressure during RFA. To reduce the pressure and ablation time, we developed a novel method of RFA, a multi-step method in which a LeVeen needle, an expansion-type electrode, is incrementally and stepwise expanded. We compared the maximal pressure during ablation and the total ablation time among the multi-step method, single-step method (a standard single-step full expansion with a LeVeen needle), and the method with a cool-tip electrode. Finally, we performed a preliminary comparison of the ablation times for these methods in HCC cases. RESULTS: A block of pig liver sealed in a rigid plastic case was used as a model of an HCC tumor with a capsule. The multi-step method with the LeVeen electrode resulted in the lowest pressure as compared with the single-step or cool-tip methods. There was no significant difference in the ablation time between the multi-step and cool-tip ablation methods, although the single-step methods had longer ablation times than the other ablation procedures. In HCC cases, the multi-step method had a significantly shorter ablation time than the single-step or cool-tip methods. CONCLUSION: We demonstrated that the multi-step method was useful to reduce the ablation time and to suppress the increase in pressure. The multi-step method using a LeVeen needle may be a clinically applicable procedure for RFA.[1]

References

Comparison of tissue pressure and ablation time between the LeVeen and cool-tip needle methods. Nakamuta, M., Kohjima, M., Morizono, S., Yoshimoto, T., Miyagi, Y., Sakai, H., Enjoji, M., Kotoh, K. Comparative hepatology (2006) [Pubmed]

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