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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Osteoprotegerin Reduces the Serum Level of Receptor Activator of NF-{kappa}B Ligand Derived from Osteoblasts.

Osteoprotegerin ( OPG) is a decoy receptor for receptor activator of NF-kappaB ligand ( RANKL). We previously reported that OPG deficiency elevated the circulating level of RANKL in mice. Using OPG(-/-) mice, we investigated whether OPG is involved in the shedding of RANKL by cells expressing RANKL. Osteoblasts and activated T cells in culture released a large amount of RANKL in the absence of OPG. OPG or a soluble form of receptor activator of NF-kappaB (the receptor of RANKL) suppressed the release of RANKL from those cells. OPG- and T cell-double-deficient mice showed an elevated serum RANKL level equivalent to that of OPG(-/-) mice, indicating that circulating RANKL is mainly derived from bone. The serum level of RANKL in OPG(-/-) mice was increased by ovariectomy or administration of 1alpha,25-dihydroxyvitamin D(3). Expression of RANKL mRNA in bone, but not thymus or spleen, was increased in wild-type and OPG(-/-) mice by 1alpha,25-dihydroxyvitamin D(3). These results suggest that OPG suppresses the shedding of RANKL from osteoblasts and that the serum RANKL in OPG(-/-) mice exactly reflects the state of bone resorption.[1]

References

  1. Osteoprotegerin Reduces the Serum Level of Receptor Activator of NF-{kappa}B Ligand Derived from Osteoblasts. Nakamichi, Y., Udagawa, N., Kobayashi, Y., Nakamura, M., Yamamoto, Y., Yamashita, T., Mizoguchi, T., Sato, M., Mogi, M., Penninger, J.M., Takahashi, N. J. Immunol. (2007) [Pubmed]
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