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Milano, S. et al.

Effect of isoprinosine on IL-2, IFN-gamma and IL-4 production in vivo and in vitro.

The effects of an immunopotentiating drug, isoprinosine, on the splenocytes of BALB/c mice to produce cytokines were investigated. Isoprinosine enhanced IL-2 production, upregulating the expression of IL-2 receptor in vitro. It also significantly increased the IFN-gamma secretion and decreased the IL-4 production in vivo. The significance of these findings in terms of immune regulation is discussed.[1]

References

Effect of isoprinosine on IL-2, IFN-gamma and IL-4 production in vivo and in vitro. Milano, S., Dieli, M., Millott, S., Miceli, M.D., Maltese, E., Cillari, E. Int. J. Immunopharmacol. (1991) [Pubmed]

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