Regulatory T cells and the eye.
Immune-mediated inflammation can be tolerated in many organs, however in the eye it has devastating consequences, as many of the tissues in the visual axis have limited or no capacity for regeneration. Multiple mechanisms and anatomical adaptations limit the expression of immune-mediated inflammation in the eye. Among these is the generation of regulatory T (T reg) cells, which act to prevent the induction and expression of T cell inflammation. At least four different pathways exist for the development of ocular Treg cells. The redundancy in the generation of T reg cells is a testament to their importance in restricting intraocular inflammation and preserving vision.[1]References
- Regulatory T cells and the eye. Niederkorn, J.Y. Chem. Immunol. Allergy (2007) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
