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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Regulatory molecules for the 5-HT3 receptor ion channel gating system.

Substituted benzoxazole derivatives which possess a nitrogen-containing heterocycle at C2 are selective partial agonists of the 5-HT(3) receptor. Alteration of substituents on the benzoxazole nucleus affords both agonist-like and antagonist-like compounds, and uniquely modifies the function of the 5-HT(3) receptor ion channel gating system. SAR and corroborative computational docking study for these partial agonists successfully explained structure and function of the 5-HT(3) receptor.[1]

References

  1. Regulatory molecules for the 5-HT3 receptor ion channel gating system. Yoshida, S., Watanabe, T., Sato, Y. Bioorg. Med. Chem. (2007) [Pubmed]
 
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