Biotransformation of (+)-cycloisolongifolol by plant pathogenic fungus Glomerella cingulata

Nat Prod Res. 2007 May;21(5):455-60. doi: 10.1080/14786410601083894.

Abstract

The biotransformation of terpenoids using the plant pathogenic fungus as a biocatalyst to produce useful novel organic compounds was investigated. The biotransformation of sesquiterpen alcohol, (+)-cycloisolongifolol (1) was investigated using plant pathogenic fungus Glomerella cingulata as a biocatalyst. Compound 1 gave one major metabolic product and a number of minor metabolic products. Major product was dehydration at the C-8 position to (+)-dehydrocycloisolongifolene (2). The structure of the product was determined by their spectroscopic data. Glomerella cingulata gave dehydration in the specifically and over 70% conversion.

MeSH terms

  • Biotransformation
  • Hydrogen-Ion Concentration
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Phyllachorales / metabolism*
  • Plants / microbiology*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / metabolism*
  • Time Factors

Substances

  • Sesquiterpenes
  • isolongifolol