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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Clinical contrast sensitivity testing in patients with infantile nystagmus syndrome compared with age-matched controls.

PURPOSE: To compare contrast sensitivity using a commercially available technique between patients with infantile nystagmus syndrome (INS) and controls. DESIGN: Prospective, comparative case series. METHODS: The functional acuity contrast test (FACT) was used binocularly in patients with INS and aged-matched controls with best acuity under normal lighting using a progression of high-quality sine wave grating size changes with increasing spatial frequencies. RESULTS: Nine INS patients aged 5 to 11 years and 25 controls were tested. The INS patients' best binocular acuity ranged from 20/125 to 20/30, and that of the controls was 20/25 or better. When compared with age-matched controls, INS patients displayed deficiencies in contrast sensitivity syndrome using the FACT test. CONCLUSIONS: The FACT or a similar testing system may have potential as a commercially available outcome measure in clinical trials in patients with INS.[1]


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