Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Freedman, D.S. et al.

David S. Freedman, Henry S. Kahn, Zuguo Mei, Laurence M. Grummer-Strawn, William H. Dietz, Sathanur R. Srinivasan, Gerald S. Berenson,

Relation of body mass index and waist-to-height ratio to cardiovascular disease risk factors in children and adolescents: the Bogalusa Heart Study.

BACKGROUND: Several investigators have concluded that the waist-to-height ratio is more strongly associated with cardiovascular disease risk factors than is the body mass index (BMI; in kg/m(2)). OBJECTIVES: We examined the relation of the BMI-for-age z score and waist-to-height ratio to risk factors (lipids, fasting insulin, and blood pressures). We also compared the abilities of these 2 indexes to identify children with adverse risk factors. DESIGN: Children aged 5-17 y (n=2498) in the Bogalusa Heart Study were evaluated. RESULTS: As assessed by the ability of the 2 indexes to 1) account for the variability in each risk factor and 2) correctly identify children with adverse values, the predictive abilities of the BMI-for-age z score and waist-to-height ratio were similar. Waist-to-height ratio was slightly better (0.01-0.02 higher R(2) values, P<0.05) in predicting concentrations of total-to-HDL cholesterol ratio and LDL cholesterol, but BMI was slightly better in identifying children with high systolic blood pressure (0.03 higher R(2), P<0.05) in predicting measures of fasting insulin and systolic and diastolic blood pressures. On the basis of an overall index of the 6 risk factors, no difference was observed in the predictive abilities of BMI-for-age and waist-to-height ratio, with areas under the curves of 0.85 and 0.86 (P=0.30) and multiple R(2) values of 0.320 and 0.318 (P=0.79). This similarity likely results from the high intercorrelation (R(2)=0.78) between the 2 indexes. CONCLUSIONS: BMI-for-age and waist-to-height ratio do not differ in their abilities to identify children with adverse risk factors. Although waist-to-height ratio may be preferred because of its simplicity, additional longitudinal data are needed to examine its relation to disease.[1]

References

Relation of body mass index and waist-to-height ratio to cardiovascular disease risk factors in children and adolescents: the Bogalusa Heart Study. Freedman, D.S., Kahn, H.S., Mei, Z., Grummer-Strawn, L.M., Dietz, W.H., Srinivasan, S.R., Berenson, G.S. Am. J. Clin. Nutr. (2007) [Pubmed]

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