- Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner. Jang, B.C., Sung, S.H., Park, J.G., Park, J.W., Bae, J.H., Shin, D.H., Park, G.Y., Han, S.B., Suh, S.I. J. Biol. Chem. (2007)