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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A concise synthesis of (S)-N-ethoxycarbonyl-alpha-methylvaline.

A practical and efficient protocol for the three-step synthesis of (S)-N-ethoxycarbonyl-alpha-methylvaline 3 is described which utilizes readily available commercial starting materials. The key transformations involve resolution-crystallization of tartrate salt 6 followed by a one-pot procedure for the preparation of 3 which is isolated as the dicyclohexylamine salt in 45% overall yield and in 91-95% ee.[1]

References

  1. A concise synthesis of (S)-N-ethoxycarbonyl-alpha-methylvaline. Kuethe, J.T., Gauthier, D.R., Beutner, G.L., Yasuda, N. J. Org. Chem. (2007) [Pubmed]
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