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Impey, S.

Soren Impey,

A histone deacetylase regulates addiction.

Epigenetic modification of chromatin has been proposed to translate environmental stimuli into persistent "cellular memories." Recent studies suggest that epigenetic pathways regulate long-term behavioral adaptation in the nervous system. In this issue of Neuron, Renthal et al. utilize genetic manipulations of HDAC5 to provide strong evidence for a role for histone acetylation in the behavioral response to cocaine.[1]

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A histone deacetylase regulates addiction. Impey, S. Neuron (2007) [Pubmed]

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