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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mass spectrometry-based survey of age-associated protein carbonylation in rat brain mitochondria.

There is a body of evidence lending credence to the idea that oxidative stress may be responsible for age-related deleterious changes in brain function, and that protein carbonylation is a potential marker for such changes. An investigation of oxidative damage to mitochondrial proteins from aged rat brains was done using gel electrophoresis coupled with carbonylation-specific immunostaining. Six proteins that appeared to be susceptible to oxidative modification were identified by in-gel trypsin digestion followed by matrix-assisted laser desorption/ionization mass spectrometry and tandem mass spectrometry. Two subunits of the H(+)-transporting ATP synthase, adenine nucleotide translocator, voltage-dependent anion channel, glutamate oxaloacetate transaminase, and aconitase were identified as likely targets of age-associated carbonylation.[1]

References

  1. Mass spectrometry-based survey of age-associated protein carbonylation in rat brain mitochondria. Prokai, L., Yan, L.J., Vera-Serrano, J.L., Stevens, S.M., Forster, M.J. J. Mass. Spectrom (2007) [Pubmed]
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