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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Preparative separation and analysis of the enantiomers of [3H]Abbott-69992, an HIV anti-infective nucleoside, by ligand-exchange high-performance liquid chromatography.

Several chiral stationary phases (CSPs) were examined to separate the enantiomers of A-69992, a chiral HIV anti-infective nucleoside. The only CSP found to be effective was Nucleosil Chiral-1, a ligand-exchange CSP, which was used to prepare microgram amounts of the enantiomers of high optical purity. This appears to be the first separation of the enantiomers of a nucleoside by chiral high-performance liquid chromatography.[1]

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