In vitro activities of 35 double combinations of antifungal agents against Scedosporium apiospermum and Scedosporium prolificans

Antimicrob Agents Chemother. 2008 Mar;52(3):1136-9. doi: 10.1128/AAC.01160-07. Epub 2008 Jan 14.

Abstract

Activities of 35 combinations of antifungal agents against Scedosporium spp. were analyzed by a checkerboard microdilution design and the summation of fractional concentration index. An average indifferent effect was detected apart from combinations of azole agents and echinocandins against Scedosporium apiospermum. Antagonism was absent for all antifungal combinations against both species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / metabolism*
  • Antifungal Agents / pharmacology*
  • Drug Interactions
  • Drug Synergism
  • Drug Therapy, Combination
  • Humans
  • Microbial Sensitivity Tests / methods
  • Mycetoma / microbiology
  • Scedosporium / classification
  • Scedosporium / drug effects*
  • Scedosporium / isolation & purification

Substances

  • Antifungal Agents