- cT3N0 rectal cancer: potential overtreatment with preoperative chemoradiotherapy is warranted. Guillem, J.G., Díaz-González, J.A., Minsky, B.D., Valentini, V., Jeong, S.Y., Rodriguez-Bigas, M.A., Coco, C., Leon, R., Hernandez-Lizoain, J.L., Aristu, J.J., Riedel, E.R., Nitti, D., Wong, W.D., Pucciarelli, S. J. Clin. Oncol. (2008)