Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Metra, M. et al.

Marco Metra, Savina Nodari, Giovanni Parrinello, Tania Bordonali, Silvia Bugatti, Rossella Danesi, Benedetta Fontanella, Carlo Lombardi, Patrizia Milani, Giulia Verzura, Gadi Cotter, Howard Dittrich, Barry M. Massie, Livio Dei Cas,

Worsening renal function in patients hospitalised for acute heart failure: clinical implications and prognostic significance.

BACKGROUND: Renal function is a powerful prognostic variable in patients with heart failure (HF). Hospitalisations for acute HF (AHF) may be associated with further worsening of renal function (WRF). METHODS AND RESULTS: We analysed the clinical significance of WRF in 318 consecutive patients admitted at our institute for AHF. WRF was defined as the occurrence, at any time during the hospitalisation, of both a > or =25% and a > or =0.3 mg/dL increase in serum creatinine (s-Cr) from admission (WRF-Abs-%). RESULTS: Patients were followed for 480+/-363 days. Fifty-three patients (17%) died and 132 (41%) were rehospitalised for HF. WRF-Abs-% occurred in 107 (34%) patients. At multivariable survival analysis, WRF-Abs-% was an independent predictor of death or HF rehospitalisation (adjusted HR, 1.47; 95%CI, 1.13-1.81; p=0.024). The independent predictors of WRF-Abs-%, evaluated using multivariable logistic regression, were history of chronic kidney disease (p=0.002), LV ejection fraction (p=0.012), furosemide daily dose (p=0.03) and NYHA class (p=0.05) on admission. CONCLUSION: WRF is a frequent finding in patients hospitalised for AHF and is associated with a poor prognosis. Severity of HF and daily furosemide dose are the most important predictors of the occurrence of WRF.[1]

References

Worsening renal function in patients hospitalised for acute heart failure: clinical implications and prognostic significance. Metra, M., Nodari, S., Parrinello, G., Bordonali, T., Bugatti, S., Danesi, R., Fontanella, B., Lombardi, C., Milani, P., Verzura, G., Cotter, G., Dittrich, H., Massie, B.M., Dei Cas, L. Eur. J. Heart Fail. (2008) [Pubmed]

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