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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Beta-N-acetylhexosaminidase activity in mouse oocytes and preimplantation embryos.

Beta-N-Acetylhexosaminidase is a lysosomal enzyme; mutation in this protein leads to Tay-Sachs or Sandhoff disease. We have developed an assay for the beta-N-acetylhexosaminidase in mouse oocytes and preimplantation embryos. Activity was low in oocytes and zygotes and started to rise from the late 2-cell stage. By using alpha-amanitin, an inhibitor of DNA-dependent RNA polymerase, we were able to show that the first embryonic mRNA transcriptions of the beta-N-acetylhexosaminidase genes take place between 38 and 46 h post HCG (early 2-cell stage) and between 46 and 54 h post HCG (late 2-cell stage).[1]

References

  1. Beta-N-acetylhexosaminidase activity in mouse oocytes and preimplantation embryos. Sermon, K., Nijs, M., Lissens, W., Van Steirteghem, A.C., Liebaers, I. Hum. Reprod. (1991) [Pubmed]
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