The pathophysiology of chronic ischemic heart disease

Clin Cardiol. 2007 Feb;30(2 Suppl 1):I4-9. doi: 10.1002/clc.20048.

Abstract

With our success in management of acute coronary syndromes (ACS), aging population and epidemics of diabetes and obesity, the management of patients with chronic coronary artery disease is becoming an increasing important part of clinical practice. Although the rates of death and myocardial infarction (MI) in this group of patients are not high as a group, a subgroup has very high risk but many have poor quality of life related to limiting angina. The purpose of this article is to review the pathophysiology of the chronic angina syndrome to provide an improved understanding of the basis for the comprehensive management required to yield patient benefits. Where possible, targets for novel therapeutic approaches are highlighted.

Publication types

  • Review

MeSH terms

  • Anemia / complications
  • Angina Pectoris / diagnosis
  • Angina Pectoris / physiopathology
  • Angina Pectoris / therapy
  • Chronic Disease
  • Coronary Artery Disease / pathology
  • Coronary Artery Disease / physiopathology
  • Coronary Circulation / physiology
  • Coronary Thrombosis / complications
  • Coronary Vessels / pathology
  • Coronary Vessels / physiopathology
  • Endothelium, Vascular / physiopathology
  • Heart / physiopathology*
  • Humans
  • Muscle, Smooth, Vascular / physiopathology
  • Myocardial Ischemia / diagnosis
  • Myocardial Ischemia / physiopathology*
  • Myocardial Ischemia / therapy
  • Myocardium / metabolism*
  • Oxygen / metabolism

Substances

  • Oxygen