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Rhoads, R.E.

Protein synthesis, cell growth and oncogenesis.

Two lines of investigation support a new hypothesis concerning the role of protein synthesis in the mitogenic pathway. The first is that a variety of mitogens and oncogene products increase phosphorylation and thereby activate eIF-4E, which is involved in the rate-limiting transfer of mRNA to ribosomes. The second is that overexpression or microinjection of eIF-4E induce rapid cell proliferation and oncogenic transformation.[1]

References

Protein synthesis, cell growth and oncogenesis. Rhoads, R.E. Curr. Opin. Cell Biol. (1991) [Pubmed]

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