Abstract
p21-activated kinases are important signaling kinases for which no specific chemical inhibitors are known. In this issue of Chemistry & Biology, Deacon et al. target allosteric transitions undergone during PAK activation to identify a selective inhibitor (Deacon et al., 2008).
MeSH terms
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Animals
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Disulfides / chemistry
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Disulfides / metabolism
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Disulfides / pharmacology
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Drug Evaluation, Preclinical / methods*
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Enzyme Activation / drug effects
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Homeostasis / drug effects
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Mice
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Protein Conformation / drug effects
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Protein Kinase Inhibitors / metabolism*
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Protein Kinase Inhibitors / pharmacology*
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Substrate Specificity
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p21-Activated Kinases / antagonists & inhibitors*
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p21-Activated Kinases / metabolism*
Substances
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Disulfides
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Protein Kinase Inhibitors
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p21-Activated Kinases