Targeting the endocannabinoid system: to enhance or reduce?

Nat Rev Drug Discov. 2008 May;7(5):438-55. doi: 10.1038/nrd2553.

Abstract

As our understanding of the endocannabinoids improves, so does the awareness of their complexity. During pathological states, the levels of these mediators in tissues change, and their effects vary from those of protective endogenous compounds to those of dysregulated signals. These observations led to the discovery of compounds that either prolong the lifespan of endocannabinoids or tone down their action for the potential future treatment of pain, affective and neurodegenerative disorders, gastrointestinal inflammation, obesity and metabolic dysfunctions, cardiovascular conditions and liver diseases. When moving to the clinic, however, the pleiotropic nature of endocannabinoid functions will require careful judgement in the choice of patients and stage of the disorder for treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Cannabinoid Receptor Modulators / metabolism*
  • Cannabinoids / therapeutic use*
  • Central Nervous System Diseases / drug therapy*
  • Central Nervous System Diseases / metabolism
  • Central Nervous System Diseases / pathology
  • Endocannabinoids*
  • Gastrointestinal Diseases / drug therapy*
  • Gastrointestinal Diseases / metabolism
  • Gastrointestinal Diseases / pathology
  • Humans
  • Metabolic Diseases / drug therapy*
  • Metabolic Diseases / metabolism
  • Metabolic Diseases / pathology
  • Models, Biological
  • Neurodegenerative Diseases / drug therapy*
  • Neurodegenerative Diseases / metabolism
  • Neurodegenerative Diseases / pathology

Substances

  • Cannabinoid Receptor Modulators
  • Cannabinoids
  • Endocannabinoids