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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Role of myeloperoxidase-mediated modification of human blood lipoproteins in atherosclerosis development.

The mechanism of interaction of hypochlorite and hypobromite formed in myeloperoxidase catalysis with lipids of human blood low-density lipoprotein is described. Both agents react with unsaturated lipids via two mechanisms: molecular (with the formation of mainly chloro- or bromohydrins and lysophospholipids) and free-radical (paralleled by lipid peroxidation). These reactions modify physicochemical properties of low-density lipoproteins and disorder their lipid-transporting function thus initiating early stages of atherosclerosis development.[1]

References

  1. Role of myeloperoxidase-mediated modification of human blood lipoproteins in atherosclerosis development. Panasenko, O.M., Vakhrusheva, T.V., Vlasova, I.I., Chekanov, A.V., Baranov, Y.V., Sergienko, V.I. Bull. Exp. Biol. Med. (2007) [Pubmed]
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