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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A-kinase anchoring proteins as the basis for cAMP signaling.

Common challenges to any cell are the processing of the extracellular stimuli it receives into intracellular signaling cascades that initiate a multitude of diverse biological functions. However, many of these stimuli act via a common signaling pathway, suggesting the cell must somehow discriminate between different stimuli and respond accordingly. Subcellular targeting through the association with adaptor and scaffolding proteins has emerged as a key mechanism by which cells maintain signaling specificity. Compartmentation of cAMP signaling is maintained by the clustering of cAMP signaling enzymes in discrete units by the scaffolding protein A-kinase anchoring proteins (AKAP). In doing so, AKAPs provide the molecular architecture for the cAMP micordomains that underlie the spacial-temporal control of cAMP signaling.[1]

References

  1. A-kinase anchoring proteins as the basis for cAMP signaling. Dodge-Kafka, K.L., Bauman, A., Kapiloff, M.S. Handb. Exp. Pharmacol (2008) [Pubmed]
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