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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Colabufo, N.A. et al.

Nicola Antonio Colabufo, Francesco Berardi, Marialessandra Contino, Carmela Inglese, Mauro Niso, Roberto Perrone,

Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.

Several reference compounds such as Cyclosporin A, Tamoxifen, Verapamil, and our compound 1, known as P-gp modulators, have been tested for their P-gp modulating activity in isolated organ bath. Compound 1 showed the best result in organ bath experiment (EC(50)=14.7 microM), Cyclosporin A and Tamoxifen displayed EC(50)=25.2 and 39.4 microM, respectively.[1]

References

Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum. Colabufo, N.A., Berardi, F., Contino, M., Inglese, C., Niso, M., Perrone, R. Bioorg. Med. Chem. Lett. (2008) [Pubmed]

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