Protein kinase Cepsilon: multiple roles in the function of, and signaling mediated by, the cytoskeleton

FEBS J. 2008 Aug;275(16):3995-4004. doi: 10.1111/j.1742-4658.2008.06557.x. Epub 2008 Jul 11.

Abstract

Recent studies have established essential roles of protein kinase Cepsilon in signaling pathways controlling various functions of microfilaments and intermediate filaments by modulating multiple cytoskeletal proteins. This review summarizes recent progress in our understanding of the roles of protein kinase Cepsilon in the functions and signaling of microfilaments and intermediate filaments, with a focus mainly on cell-matrix and cell-cell interactions, migrations and contraction, in addition to its relevance in the development of several diseases, such as malignant tumors or cardiac disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / enzymology*
  • Animals
  • Cardiomyopathies / enzymology
  • Cell Adhesion
  • Cell Movement
  • Extracellular Matrix / physiology
  • Integrins / metabolism
  • Intermediate Filaments / enzymology*
  • Neoplasms / enzymology
  • Protein Kinase C-epsilon / physiology*
  • Signal Transduction*

Substances

  • Integrins
  • Protein Kinase C-epsilon