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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Genetic thrombophilia variants and risk for preeclampsia among American Indians.

OBJECTIVE: To determine the prevalence of thrombophilic genetic variants in an American Indian population and determine if they are associated with preeclampsia. METHODS: A total of 87 cases, 165 controls and an additional 75 population-based controls were genotyped for two thrombophilic polymorphisms. RESULTS: The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin variants in this population was 2.1% and 0.5% respectively. No statistically significant associations between these genetic variants and preeclampsia were found. CONCLUSION: The prevalence of thrombophilic variants is of possible public health significance for other morbidity; but perhaps not in relation to preeclampsia.[1]

References

  1. Genetic thrombophilia variants and risk for preeclampsia among American Indians. Best, L.G., Dorsam, S.T., Nadeau, M., Burd, L., Anderson, C.M. Hypertens. Pregnancy (2009) [Pubmed]
 
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