The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

The Z-disk diseases.

Recent studies have identified disease-causing mutations in four genes that encode Z-disk proteins. Mutations in myotilin (MYOT), ZASP and filamin C (FLNC) encoding genes cause autosomal dominant myopathy that manifests in adulthood. The clinical features and morphological changes in myopathies caused by mutations in all three genes are highly similar. The disease typically manifests as distal myopathy, but may also affect proximal muscles and the heart. The morphological findings are typical of myofibrillar myopathy (MFM) and include Z-disk alterations and aggregation of dense filamentous material visible in trichrome staining. The disease mechanism is still unclear, but may involve structural alterations of the Z-disk caused by dysfunctional proteins or their abnormal accumulation due to defective degradation. Although the fourth gene product, telethonin, is also involved in the Z-disk organization, its mutations cause a different phenotype. Telethonin mutations result in recessive muscular dystrophy, which manifests in childhood as proximal weakness. The morphologic alterations caused by telethonin mutations are not well characterized, but may share common features of MFM. Future work aims at understanding the pathophysiology of Z-disk related disorders and identification of novel genetic defects in patients with morphological features of MFM.[1]

References

  1. The Z-disk diseases. Selcen, D., Carpén, O. Adv. Exp. Med. Biol. (2008) [Pubmed]
 
WikiGenes - Universities