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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE.

A series of N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)-butan-2-yl)benzamides has been synthesized as BACE inhibitors. A variety of P2 and P3 substituents has been explored, and these efforts have culminated in the identification of several 1,3,5-trisubstituted phenylcarboxyamides with potent BACE inhibitory activity.[1]

References

  1. Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE. Wu, Y.J., Zhang, Y., Good, A.C., Burton, C.R., Toyn, J.H., Albright, C.F., Macor, J.E., Thompson, L.A. Bioorg. Med. Chem. Lett. (2009) [Pubmed]
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