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Golimbet, V.E. et al.

V.E. Golimbet, I.S. Lebedeva, G.I. Korovaitseva, T.V. Lezheiko, P.E. Yumatova,

Association of 5-HTTLPR serotonin transporter gene polymorphism and Val66Met brain-derived neurotrophic factor gene polymorphism with auditory N100 evoked potential amplitude in patients with endogenous psychoses.

We studied the relationship between genes of serotonin transporter and brain-derived neurotrophic factor and parameters of AEP N100 wave to a non-significant stimulus in patients with endogenous mental diseases. In patients with endogenous psychoses, a significant effect of BDNF Val66Met marker on N100 wave amplitude was revealed: the mean N100 amplitude was higher in carriers of Val/Val genotype compared to Val/Met genotype carriers. The effect of the 5-HTTLPR marker on the wave amplitude was less pronounced (tendency): the SS genotype was associated with higher N100 amplitude.[1]

References

Association of 5-HTTLPR serotonin transporter gene polymorphism and Val66Met brain-derived neurotrophic factor gene polymorphism with auditory N100 evoked potential amplitude in patients with endogenous psychoses. Golimbet, V.E., Lebedeva, I.S., Korovaitseva, G.I., Lezheiko, T.V., Yumatova, P.E. Bull. Exp. Biol. Med. (2008) [Pubmed]

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