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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.

FANCI is integral to the Fanconi anemia (FA) pathway of DNA damage repair. Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 and relocalizes to chromatin, where it functions with monoubiquitinated FANCD2 to facilitate DNA repair. We show that FANCI and its C-terminal fragment possess a DNA binding activity that prefers branched structures. We also demonstrate that FANCI can be ubiquitinated on Lys-523 by the UBE2T-FANCL pair in vitro. These findings should facilitate future efforts directed at elucidating molecular aspects of the FA pathway.[1]

References

  1. FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL. Longerich, S., San Filippo, J., Liu, D., Sung, P. J. Biol. Chem. (2009) [Pubmed]
 
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