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Völzke, H. et al.

Henry Völzke, Matthias Nauck, Rainer Rettig, Marcus Dörr, Claire Higham, Georg Brabant, Henri Wallaschofski,

Association between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample.

CONTEXT: It is assumed that hepatic steatosis plays a role in the development and progression of the metabolic syndrome and its cardiovascular sequelae. Low serum IGF1 levels might mediate these associations. OBJECTIVES: The aims of this study were i) to investigate the associations of hepatic steatosis with serum IGF1 and IGF binding protein-3 (IGFBP-3) levels using ultrasound and serum alanine aminotransaminase (ALT) data to define hepatic steatosis, and ii) to analyze the specific role of alcohol consumption in this context. DESIGN: We analyzed data from the population-based Study of Health in Pomerania. METHODS: We used data from 3863 subjects (1971 women) aged 20-79 years who had no history of viral hepatitis, liver cirrhosis, or malignant diseases. Liver hyperechogenicity was diagnosed using ultrasound. Serum IGF1 and IGFBP-3 levels were determined by automated two-site chemiluminescence immunoassays. RESULTS: Hyperechogenic liver pattern was associated with low serum IGF1 levels and low serum IGF1/IGFBP-3 ratios. The lowest serum IGF1 and IGF1/IGFBP-3 values and highest IGFBP-3 levels were present in subjects who had a hyperechogenic liver pattern and increased serum ALT levels. All of these associations were independent of alcohol consumption. CONCLUSIONS: Our data show that hepatic steatosis is associated with low serum IGF1 levels. This association is independent of alcohol consumption.[1]

References

Association between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample. Völzke, H., Nauck, M., Rettig, R., Dörr, M., Higham, C., Brabant, G., Wallaschofski, H. Eur. J. Endocrinol. (2009) [Pubmed]

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