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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 
 

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

Mutations at the mouse dwarf locus (dw) interrupt the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. Disruptions in the gene encoding the POU-domain transcription factor, Pit-1, occur in both characterized alleles of the dwarf locus. The data indicate that Pit-1 is necessary for the specification of the phenotype of three cell types in the anterior pituitary, and directly link a transcription factor to commitment and progression events in mammalian organogenesis.[1]

References

  1. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Li, S., Crenshaw, E.B., Rawson, E.J., Simmons, D.M., Swanson, L.W., Rosenfeld, M.G. Nature (1990) [Pubmed]
 
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