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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis.

To investigate the function of activated T lymphocytes in autoimmune chronic active hepatitis, 7 of 15 T-cell clones from the peripheral blood of 8 patients were studied. These clones showed specificity for liver-membrane antigen with proliferation when stimulated by rabbit liver cell membranes. 6 of these clones reacted with liver-specific lipoprotein complex, and 1 clone (and 3 subclones) responded to the asialoglycoprotein receptor ( ASGPR), both known targets of immune attack in autoimmune chronic active hepatitis. 2 of these clones stimulated autologous B lymphocytes to produce liver-membrane-specific autoantibodies and antibody to the ASGPR. These results suggest that liver-membrane-specific activated T lymphocytes in peripheral blood may be important in the autoimmune attack of chronic active hepatitis.[1]

References

  1. T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis. Wen, L., Peakman, M., Lobo-Yeo, A., McFarlane, B.M., Mowat, A.P., Mieli-Vergani, G., Vergani, D. Lancet (1990) [Pubmed]
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