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Kaplan, S.A. et al.

Steven A. Kaplan, Evan R. Goldfischer, William D. Steers, Marc Gittelman, Masakazu Andoh, Sergio Forero-Schwanhaeuser,

Solifenacin treatment in men with overactive bladder: effects on symptoms and patient-reported outcomes.

OBJECTIVE: In the few studies to evaluate antimuscarinics for overactive bladder (OAB) in men, safety has been the primary focus. In OAB efficacy trials, subject populations have been predominantly female and patient-reported outcomes (PROs) have been assessed only recently. We present a post hoc analysis of PRO-based findings from the subset of men (without presumed bladder outlet obstruction [BOO]) from two large, independent, open-label trials of solifenacin. METHODS: Subjects with OAB for > or =3 months received flexibly dosed solifenacin for 12 weeks. At baseline and 4-week intervals, subjects completed the Patient Perception of Bladder Condition (PPBC) and Overactive Bladder Questionnaire (OAB-q). In one study, subjects also completed 3-day bladder diaries. At baseline, mean PPBC scores were similar in both studies and indicative of moderate-to-severe problems. RESULTS: After 12 weeks of solifenacin, mean PPBC scores improved significantly (p < 0.0001); values were suggestive of minor-to-moderate problems. Mean scores on the OAB-q were also significantly improved after solifenacin (p values < or =0.001). In men without presumed BOO, solifenacin significantly improved PRO measures of symptom bother, health-related quality of life, and overall perception of bladder problems. CONCLUSION: Results from these two studies support the use of solifenacin as a well-tolerated and efficacious treatment option for providing symptom relief in men with OAB without BOO.[1]

References

Solifenacin treatment in men with overactive bladder: effects on symptoms and patient-reported outcomes. Kaplan, S.A., Goldfischer, E.R., Steers, W.D., Gittelman, M., Andoh, M., Forero-Schwanhaeuser, S. Aging. Male (2010) [Pubmed]

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