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Iversen, P.O. et al.

Per Ole Iversen, Finn Wisløff, Nina Gulbrandsen,

Reduced nutritional status among multiple myeloma patients during treatment with high-dose chemotherapy and autologous stem cell support.

BACKGROUND & AIMS: Multiple myeloma (MM) ranks among the most frequent blood cancers in adults. Optimal treatment consists of high-dose chemotherapy and autologous stem cell transplantation. Health-related quality of life (HRQoL) is reduced before, during, and after therapy. Several HRQoL items are associated with nutritional health, e.g., nausea/vomiting, appetite loss and fatigue. It is unknown whether nutritional status in MM is affected by treatment. Hence we assessed nutritional status before, during and (1/2) year after treatment-start. METHODS: We applied anthropometry (height, weight, hand-grip strength, triceps skinfold) and plasma concentrations of biomarkers to assess nutritional status. HRQoL was determined with the EORTC QLQ-C30 questionnaire. RESULTS: The anthropometrical parameters all decreased (p<0.05) during treatment, but were restored at the end of the observation period. Albumin and the fat-soluble vitamins D and E followed a similar pattern, whereas transferrin and vitamin A were unchanged (p>0.05). Interestingly, markers of thyroid function declined and remained low (p<0.05) even 6 months after start of therapy. Nutrition-associated symptoms used as markers of HRQoL worsened during therapy, but returned to pre-therapy levels. CONCLUSION: Intensive therapy in MM is associated with a decline in both nutritional status and health-related quality of life.[1]

References

Reduced nutritional status among multiple myeloma patients during treatment with high-dose chemotherapy and autologous stem cell support. Iversen, P.O., Wisløff, F., Gulbrandsen, N. Clin. Nutr (2010) [Pubmed]

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