Mouse ferritin H sequences map to chromosomes 3, 6, and 19.
Human and rodent genomes contain multiple copies of ferritin H and L subunit sequences, although it is not yet clear whether there is more than one expressed gene for either of these subunits. We have isolated a cDNA corresponding to mouse ferritin H subunit and observed that the mouse genome contains three to four H-related sequences. This cDNA was used to establish the genomic location of mouse ferritin H subunit genes by chromosomal in situ hybridization. Metaphase chromosomes of concanavalin A-stimulated lymphocytes from a WMP male mouse were examined by in situ hybridization with 3H-labeled cDNA and the chromosomes were identified by R banding (fluorochrome-photolysis-Giemsa method). The results indicate that mouse ferritin H-related sequences map at chromosomes 3, 6, and 19. Homology of synteny between human and mouse suggests that the sequence on mouse chromosome 19 corresponds to the structural H gene.[1]References
- Mouse ferritin H sequences map to chromosomes 3, 6, and 19. Yachou, A., Mattei, M.G., Roeckel, N., Grandchamp, B., Beaumont, C. Genomics (1991) [Pubmed]
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