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Opal, S.M. et al.

Steven M. Opal, Yow-Pin Lim, Patricia Cristofaro, Andrew W. Artenstein, Noubar Kessimian, David Delsesto, Nicolas Parejo, John E. Palardy, Edward Siryaporn,

Inter-α inhibitor proteins: a novel therapeutic strategy for experimental anthrax infection.

Human inter-α inhibitor proteins are endogenous human plasma proteins that function as serine protease inhibitors. Inter-α inhibitor proteins can block the systemic release of proteases in sepsis and block furin-mediated assembly of protective antigen, an essential stop in the intracellular delivery of the anthrax exotoxins, lethal toxin and edema toxin. Inter-α inhibitor proteins administered on hour or up to 24 h after spore challenge with Bacillus anthracis Sterne strain protected mice from lethality if administered with antimicrobial therapy (P < 0.001). These human plasma proteins possess combined actions against anthrax as general inhibitors of excess serine proteases in sepsis and specific inhibitors of anthrax toxin assembly. Inter-α inhibitor proteins could represent a novel adjuvant therapy for the treatment of established anthrax infection.[1]

References

Inter-α inhibitor proteins: a novel therapeutic strategy for experimental anthrax infection. Opal, S.M., Lim, Y.P., Cristofaro, P., Artenstein, A.W., Kessimian, N., Delsesto, D., Parejo, N., Palardy, J.E., Siryaporn, E. Shock (2011) [Pubmed]

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